info:eu-repo/semantics/article
Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension
Fecha
2018-05Registro en:
Prado, Natalia Jorgelina; Ferder, Leon Fernando; Manucha, Walter Ariel Fernando; Diez, Emiliano Raúl; Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension; Current Medicine Group; Current Hypertension Reports; 20; 5-2018; 1-12
1522-6417
CONICET Digital
CONICET
Autor
Prado, Natalia Jorgelina
Ferder, Leon Fernando
Manucha, Walter Ariel Fernando
Diez, Emiliano Raúl
Resumen
Purpose of Review: Here, we review the known relations between hypertension and obesity to inflammation and postulate the endogenous protective effect of melatonin and its potential as a therapeutic agent. We will describe the multiple effects of melatonin on blood pressure, adiposity, body weight, and focus on mitochondrial-related anti-inflammatory and antioxidant protective effects. Recent Findings: Hypertension and obesity are usually associated with systemic and tissular inflammation. The progressive affection of target-organs involves multiple mediators of inflammation, most of them redundant, which make anti-inflammatory strategies ineffective. Melatonin reduces blood pressure, body weight, and inflammation. The mechanisms of action of this ancient molecule of protection involve multiple levels of action, from subcellular to intercellular. Mitochondria is a key inflammatory element in vascular and adipose tissue and a potential pharmacological target. Melatonin protects against mitochondrial dysfunction. Summary: Melatonin reduces blood pressure and adipose tissue dysfunction by multiple anti-inflammatory/antioxidant actions and provides potent protection against mitochondria-mediated injury in hypertension and obesity. This inexpensive and multitarget molecule has great therapeutic potential against both epidemic diseases.