info:eu-repo/semantics/article
Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
Fecha
2018-05Registro en:
Mendez, Luciana; Poeylaut Palena, Andrés Alberto; Mata, Ernesto Gabino; Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives; Molecular Diversity Preservation International; Molecules; 23; 5; 5-2018
1420-3049
CONICET Digital
CONICET
Autor
Mendez, Luciana
Poeylaut Palena, Andrés Alberto
Mata, Ernesto Gabino
Resumen
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.