info:eu-repo/semantics/article
17β-Estradiol signaling in skeletal muscle cells and its relationship to apoptosis
Fecha
2008-10Registro en:
Boland, Ricardo Leopoldo; Vasconsuelo, Andrea Anahi; Milanesi, Lorena Magdalena; Ronda, Ana Carolina; Russo, Ana Josefa; 17β-Estradiol signaling in skeletal muscle cells and its relationship to apoptosis; Elsevier Science Inc; Steroids; 73; 9-10; 10-2008; 859-863
0039-128X
CONICET Digital
CONICET
Autor
Boland, Ricardo Leopoldo
Vasconsuelo, Andrea Anahi
Milanesi, Lorena Magdalena
Ronda, Ana Carolina
Russo, Ana Josefa
Resumen
17β-Estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ERα and β. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ERβ plays a major role in the inhibition of apoptosis by 17β-estradiol at the level of mitochondria, whereas ERα and ERβ mediate the activation of Akt to the same extent, suggesting differential involvement of ER isoforms depending on the step of the apoptotic/survival pathway involved. The myopathies associated to estrogen deficit states may be related to the mechanisms by which estrogen regulates apoptosis.