info:eu-repo/semantics/publishedVersion
Free drug theory
Fecha
2021Registro en:
Talevi, Alan; Bellera, Carolina Leticia; Free drug theory; Springer; 2021; 1-6
978-3-030-51519-5
CONICET Digital
CONICET
Autor
Talevi, Alan
Bellera, Carolina Leticia
Resumen
The free drug theory (sometimes also termed free drug hypothesis) provides a conceptual framework increasingly used to understand pharmacokinetics/pharmacodynamics (PK/PD) relationships [1]. It underlines the central role of free (or unbound) drug concentration at the site of action (the surroundings of the drug target) as determinant of in vivo efficacy and pharmacokinetics. A deep understanding of this theory can also be helpful to establish in vitro-in vivo correlations or, alternatively, to provide explanations to absence of clear correlations between in vitro and in vivo studies.