info:eu-repo/semantics/article
Annonaceous Acetogenins with insecticidal effects on Spodoptera frugiperda Smith (Lepidoptera: Noctuidae)
Fecha
2018-07Registro en:
Ruiz Hidalgo, José; Parellada, Eduardo Alberto; Bardon, Alicia del Valle; Neske, Adriana Neske; Annonaceous Acetogenins with insecticidal effects on Spodoptera frugiperda Smith (Lepidoptera: Noctuidae); SCIRP; Journal of Agricultural Chemistry and Environment; 7; 3; 7-2018; 105-116
2325-7458
2325-744X
CONICET Digital
CONICET
Autor
Ruiz Hidalgo, José
Parellada, Eduardo Alberto
Bardon, Alicia del Valle
Neske, Adriana Neske
Resumen
Background: Annonaceous acetogenins enclose a large number of biological activities, among which the insecticidal stands out. Methods: We report herein the biocide effects of natural acetogenins from Annona squamosa, A. muricata and A. montana seeds: annonacin, cis-annonacin, cis-annonacin-10- one, asimicin, rolliniastatin-2, cherimolin-1, cherimolin-2, almuñequin, and two β-OH acetogenins: laherradurin and itrabin on Spodoptera frugiperda Smith (Lepidoptera: Noctuidae). Also, some acetylated and methoxy methylated ACG derivatives were synthesized and evaluated: annonacin (3 OAc), annonacin (4 OAc), asimicin (3 OAc), rolliniastatin-2 (3 OAc), rolliniastatin-2 (MOM), laherradurin (3 OAc) and itrabin (3 OAc). Results: The natural acetogenin rolliniastatin-2 (100 μg·g-1 of diet) produced the most important toxic action causing 100% mortality of early instar larvae. Derivatization of ACG yielded compounds that produced nutritional alterations. The incorporation of rolliniastatin-2 (3 OAc) and rolliniastatin-2 (3 MOM) (100 μg·g-1) into the artificial diet of Spodoptera frugiperdadisplayed the strongest antifeedant effects causing marked decreasings in larval growth and adult lethal malformations. Conclusion: Natural acetogenins are promising metabolites for insect control. Derivatization of these compounds reduces their toxicity to early instar larvae.