info:eu-repo/semantics/article
Analysis of four scales for global severity evaluation in Parkinson’s disease
Fecha
2016-05Registro en:
Martinez Martin, Pablo; Rojo Abuin, José Manuel; Rodríguez Violante, Mayela; Serrano Dueñas, Marcos; Garreto, Nélida Susana; et al.; Analysis of four scales for global severity evaluation in Parkinson’s disease; Nature Publishing Group; NPJ Parkinson's Disease; 2; 16007; 5-2016; 1-6
2373-8057
CONICET Digital
CONICET
Autor
Martinez Martin, Pablo
Rojo Abuin, José Manuel
Rodríguez Violante, Mayela
Serrano Dueñas, Marcos
Garreto, Nélida Susana
Martínez Castrillo, Juan Carlos
Campos Arillo, Víctor
Fernández, William
Chaná Cuevas, Pedro
Arakaki, Tomoko
Alvarez, Mario Gustavo
Pedroso Ibañez, Ivonne
Rodríguez Blázquez , Carmen
Ray Chaudhuri , Kallol
Merello, Marcelo Jorge
Resumen
Global evaluations of Parkinson?s disease (PD) severity are available, but their concordance and accuracy have not been previously tested. The present international, cross-sectional study was aimed at determining the agreement level among four global scales for PD (Hoehn and Yahr, HY; Clinical Global Impression of Severity, CGIS; Clinical Impression of Severity Index, CISI-PD; and Patient Global Impression of Severity, PGIS) and identifying which of them better correlates with itemized PD assessments. Assessments included additional scales for evaluation of the movement impairment, disability, affective disorders, and quality of life. Spearman correlation coefficients, weighted and generalized kappa, and Kendall?s concordance coefficient were used. Four hundred thirty three PD patients, 66% in HY stages 2 or 3, mean disease duration 8.8 years, were analyzed. Correlation between the global scales ranged from 0.60 (HY with PGIS) to 0.91 (CGIS with CISI-PD). Kendall?s coefficient of concordance resulted 0.76 (P<0.0001). HY and CISI-PD showed the highest association with age, disease duration, and levodopa-equivalent daily dose, and CISI-PD with measures of PD manifestations, disability, and quality of life. PGIS and CISI-PD correlated similarly with anxiety and depression scores. The lowest agreement in classifying patients as mild, moderate, or severe was observed between PGIS and HY or CISI-PD (58%) and the highest between CGIS and CISI-PD (84.3%). The four PD global severity scales agree moderately to strongly among them; clinician-based ratings estimate PD severity, as established by other measures, better than PGIS; and the CISI-PD showed the highest association with measures of impairment, disability, and quality of life.