info:eu-repo/semantics/article
Nitro-fatty acid formation and metabolism
Fecha
2018-09Registro en:
Buchan, Gregory J.; Bonacci, Gustavo Roberto; Fazzari, Marco; Salvatore, Sonia Rosana; Gelhaus Wendell, Stacy; Nitro-fatty acid formation and metabolism; Academic Press Inc Elsevier Science; Nitric Oxide-Biology and Chemistry; 79; 9-2018; 38-44
1089-8603
CONICET Digital
CONICET
Autor
Buchan, Gregory J.
Bonacci, Gustavo Roberto
Fazzari, Marco
Salvatore, Sonia Rosana
Gelhaus Wendell, Stacy
Resumen
Nitro-fatty acids (NO 2 -FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a considerable amount regarding NO 2 -FA signaling, endogenous formation and metabolism is relatively unexplored. This review will cover what is currently known regarding the proposed mechanisms of NO 2 -FA formation, dietary modulation of endogenous NO 2 -FA levels, pathways of NO 2 -FA metabolism and the detection of NO 2 -FA and corresponding metabolites.