info:eu-repo/semantics/article
The pedunclopontine nucleus and Parkinson's disease
Fecha
2019-08Registro en:
Tubert, Cecilia; Galtieri, Daniel; Surmeier, D. James; The pedunclopontine nucleus and Parkinson's disease; Academic Press Inc Elsevier Science; Neurobiology of Disease; 128; 8-2019; 3-8
0969-9961
CONICET Digital
CONICET
Autor
Tubert, Cecilia
Galtieri, Daniel
Surmeier, D. James
Resumen
In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.