info:eu-repo/semantics/article
Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex
Fecha
2010-06Registro en:
Carboni, Ezio; Barros, Virginia Gabriela; Ibba, Marcello; Silvagni, Alessandra; Mura, Cristina; et al.; Prenatal restraint stress: An in vivo microdialysis study on catecholamine release in the rat prefrontal cortex; Pergamon-Elsevier Science Ltd; Neuroscience; 168; 1; 6-2010; 156-166
0306-4522
CONICET Digital
CONICET
Autor
Carboni, Ezio
Barros, Virginia Gabriela
Ibba, Marcello
Silvagni, Alessandra
Mura, Cristina
Antonelli, Marta Cristina
Resumen
There is substantial evidence that prenatal exposure to adverse environmental conditions might lead to the psychiatric disorders that can appear in adolescence or in adulthood; vulnerability to drug addiction may increase as well. It is currently accepted that the alteration of catecholamine transmission in the prefrontal cortex plays a prominent role in the etiology of psychiatric disorders. We assessed basal and stimulated dopamine and noradrenaline extracellular concentration in the medial prefrontal cortex by means of microdialysis in awake male adolescent and young adult offspring of rats exposed to restraint stress in the last week of pregnancy. Catecholamine stimulation was obtained by amphetamine or nicotine. We observed that prenatal stress (PNS) did not change dopamine but decreased noradrenaline basal output in both adolescents and adults. Moreover, it decreased amphetamine stimulated dopamine output and increased amphetamine stimulated noradrenaline output. PNS decreased nicotine stimulated noradrenaline (but not dopamine output) in adults, though not in adolescents. These data show that PNS stress modifies prefrontal cortex catecholamine transmission in a complex and age dependent manner. Our results support the view that prenatal stress may be a contributing factor for the development of psychiatric disorders and that its effect may augment drug addiction vulnerability.