dc.creator | Atorrasagasti, María Catalina | |
dc.creator | Onorato, Agostina Mariana | |
dc.creator | Gimeno, Maria Laura | |
dc.creator | Andreone, Luz | |
dc.creator | García, Mariana Gabriela | |
dc.creator | Malvicini, Mariana | |
dc.creator | Fiore, Esteban Juan | |
dc.creator | Bayo Fina, Juan Miguel | |
dc.creator | Perone, Marcelo Javier | |
dc.creator | Mazzolini Rizzo, Guillermo Daniel | |
dc.date.accessioned | 2021-02-03T11:39:43Z | |
dc.date.accessioned | 2022-10-15T00:50:54Z | |
dc.date.available | 2021-02-03T11:39:43Z | |
dc.date.available | 2022-10-15T00:50:54Z | |
dc.date.created | 2021-02-03T11:39:43Z | |
dc.date.issued | 2019-01 | |
dc.identifier | Atorrasagasti, María Catalina; Onorato, Agostina Mariana; Gimeno, Maria Laura; Andreone, Luz; García, Mariana Gabriela; et al.; SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice; Portland Press; Clinical Science; 133; 2; 1-2019; 351-365 | |
dc.identifier | 0143-5221 | |
dc.identifier | http://hdl.handle.net/11336/124559 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/4326777 | |
dc.description.abstract | Obesity, metabolic syndrome, and type 2 diabetes, three strongly interrelated diseases, are associated to increased morbidity and mortality worldwide. The pathogenesis of obesity-associated disorders is still under study. Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein expressed in many cell types including adipocytes, parenchymal, and non-parenchymal hepatic cells and pancreatic cells. Studies have demonstrated that SPARC inhibits adipogenesis and promotes insulin resistance; in addition, circulating SPARC levels were positively correlated with body mass index in obese individuals. Therefore, SPARC is being proposed as a key factor in the pathogenesis of obesity-associated disorders. The aim of this study is to elucidate the role of SPARC in glucose homeostasis. We show here that SPARC null (SPARC −/− ) mice displayed an abnormal insulin-regulated glucose metabolism. SPARC −/− mice presented an increased adipose tissue deposition and an impaired glucose homeostasis as animals aged. In addition, the absence of SPARC worsens high-fat diet-induced diabetes in mice. Interestingly, although SPARC −/− mice on high-fat diet were sensitive to insulin they showed an impaired insulin secretion capacity. Of note, the expression of glucose transporter 2 in islets of SPARC −/− mice was dramatically reduced. The present study provides the first evidence that deleted SPARC expression causes diabetes in mice. Thus, SPARC deficient mice constitute a valuable model for studies concerning obesity and its related metabolic complications, including diabetes. | |
dc.language | eng | |
dc.publisher | Portland Press | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/clinsci/article-abstract/133/2/351/111047/SPARC-is-required-for-the-maintenance-of-glucose?redirectedFrom=fulltext | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1042/CS20180714 | |
dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | SPARC | |
dc.subject | GLUCOSE HOMEOSTASIS | |
dc.subject | INSULIN SECRETION | |
dc.title | SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |