article
Hepatocyte and sertoli cell aquaporins, recent advances and research trends
Autor
Bernardino, Raquel L.
Marinelli, Raúl A.
Maggio, Anna
Gena, Patrizia
Cataldo, Ilaria
Alves, Marco G.
Svelto, María
Oliveira, Pedro F.
Calamita, Giuseppe
Institución
Resumen
Aquaporins (AQPs) are proteinaceous channels widespread in nature where they allow
facilitated permeation of water and uncharged through cellular membranes. AQPs play a number
of important roles in both health and disease. This review focuses on the most recent advances
and research trends regarding the expression and modulation, as well as physiological and
pathophysiological functions of AQPs in hepatocytes and Sertoli cells (SCs). Besides their involvement
in bile formation, hepatocyte AQPs are involved in maintaining energy balance acting in hepatic
gluconeogenesis and lipid metabolism, and in critical processes such as ammonia detoxification
and mitochondrial output of hydrogen peroxide. Roles are played in clinical disorders including
fatty liver disease, diabetes, obesity, cholestasis, hepatic cirrhosis and hepatocarcinoma. In the
seminiferous tubules, particularly in SCs, AQPs are also widely expressed and seem to be implicated
in the various stages of spermatogenesis. Like in hepatocytes, AQPs may be involved in maintaining
energy homeostasis in these cells and have a major role in the metabolic cooperation established
in the testicular tissue. Altogether, this information represents the mainstay of current and future
investigation in an expanding field. Para citar este articulo: Bernardino, R.L.; Marinelli, R.A.; Maggio, A.; Gena, P.; Cataldo, I.; Alves, M.G.; Svelto, M.; Oliveira, P.F.; Calamita, G. Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends. Int. J. Mol. Sci. 2016, 17, 1096. https://doi.org/10.3390/ijms17071096 Fil: Bernardino, Raquel L. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Unit for Multidisciplinary Research in Biomedicine (UMIB); Portugal. Fil: Bernardino, Raquel L. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Department of Microscopy, Laboratory of Cell Biology; Portugal. Fil: Marinelli, Raúl A. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental (IFISE -CONICET); Argentina. Fil: Maggio, Anna. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Gena, Patrizia. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Cataldo, Ilaria. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Alves, Marco G. University of Beira Interior. CICS-UBI, Health Sciences Research Centre; Portugal. Fil: Svelto, María. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharnaceutics; Italy. Fil: Oliveira, Pedro F. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Unit for Multidisciplinary Research in Biomedicine (UMIB); Portugal. Fil: Oliveira, Pedro F. University of Porto. Institute of Biomedical Sciences Abel Salazar (ICBAS). Department of Microscopy, Laboratory of Cell Biology; Portugal. Fil: Oliveira, Pedro F. Universidade do Porto. Instituto de Investigação e Inovação em Saúde; Portugal. Fil: Calamita, Giuseppe. University of Bari “Aldo Moro”. Department of Biosciences, Biotechnologies and Biopharmaceutics; Italy.