Post-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation

dc.contributorAFIP
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorHosp Rim & Hipertensao
dc.contributorUniv Fed Parana
dc.creatorGrenzi, Patricia C. [UNIFESP]
dc.creatorCampos, Erika F. [UNIFESP]
dc.creatorSilva, Helio T.
dc.creatorFelipe, Claudia R.
dc.creatorFranco, Marcelo F. [UNIFESP]
dc.creatorSoares, Maria F.
dc.creatorMedina-Pestana, Jose O. [UNIFESP]
dc.creatorGerbase-DeLima, Maria [UNIFESP]
dc.date.accessioned2016-01-24T14:40:11Z
dc.date.accessioned2022-10-07T21:09:42Z
dc.date.available2016-01-24T14:40:11Z
dc.date.available2022-10-07T21:09:42Z
dc.date.created2016-01-24T14:40:11Z
dc.date.issued2015-03-01
dc.identifierTransplant Immunology. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 61-65, 2015.
dc.identifier0966-3274
dc.identifierhttp://repositorio.unifesp.br/handle/11600/38843
dc.identifier10.1016/j.trim.2015.02.004
dc.identifierWOS:000353072800001
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/4027174
dc.description.abstractSeveral studies have shown association of high pre- or post-transplant levels of soluble CD30 (sCD30) with acute rejection and poor late kidney transplant outcome. Our goal was to investigate whether sCD30 levels at month-3 post-transplant are associated with subclinical rejection, presence of CD30(+) cells within the graft, and expression of immune response genes in peripheral blood mononuclear cells. the study comprised 118 adult first kidney graft recipients, transplanted at a single center, receiving tacrolimus in low concentration. All were submitted to a protocol biopsy at month-3. Subclinical rejection was identified in 10 biopsies and sCD30 levels >= 61.88 ng/mL (P = 0.004), younger recipient age (P = 0.030) and non-Caucasian ethnicity (P = 0.011) were independently associated with this outcome. Rare CD30(+) cells were present in only two biopsies. There was a correlation between sCD30 levels and CD30 gene expression in peripheral blood mononuclear cells (r = 0.385, P = 0.043). These results show that high sCD30 levels are independent predictors of graft dysfunction and may contribute to patient selection protocols by indicating those who could benefit from a more thorough evaluation. (C) 2015 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationTransplant Immunology
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.rightsAcesso restrito
dc.subjectsCD30
dc.subjectSubclinical rejection
dc.subjectKidney transplantation
dc.subjectPost-transplant monitoring
dc.subjectProtocol biopsy
dc.titlePost-transplant soluble CD30 levels are associated with early subclinical rejection in kidney transplantation
dc.typeArtigo


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