Efectos farmacológicos y comportamentales de la administración crónica de nicotina en una tarea de automoldeamiento

dc.contributorLamprea Rodríguez, Marisol
dc.contributorOrtega Murillo, Leonardo Augusto
dc.contributorNeurociencia Básica y Cognoscitiva
dc.creatorCampos León, Estrella Lirdeya
dc.date.accessioned2022-07-05T13:05:40Z
dc.date.available2022-07-05T13:05:40Z
dc.date.created2022-07-05T13:05:40Z
dc.date.issued2022-06-20
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/81675
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co/
dc.description.abstractLa investigación actual ha destacado la importancia del aprendizaje asociativo en la adicción. Se ha mostrado que por medio de procedimientos pavlovianos las claves asociadas a un estímulo apetitivo como una droga pueden adquirir saliencia de incentivo, volviéndose más atractivas y facilitando comportamientos de búsqueda de droga y recaída. La asignación de saliencia de incentivo puede variar según el fenotipo de los sujetos (goal trackers o sign trackers). Aunque en ambos fenotipos el estímulo condicionado (EC) adquiere valor predictivo sobre el estímulo incondicionado (EI), solo en los sign trackers el EC adquiere saliencia de incentivo. Al respecto, se ha reportado que la nicotina tiene la capacidad de amplificar el valor de incentivo de claves asociadas a estímulos apetitivos como la comida o el agua. El presente estudio tuvo como objetivo evaluar los efectos de la administración crónica de nicotina en la adquisición de una tarea de automoldeamiento y la expresión de FosB/DFosB en áreas relacionadas con la saliencia de incentivo. 61 ratas macho Wistar clasificadas como sign trackers fueron entrenadas en una tarea de automoldeamiento donde se emparejó la presentación de una palanca con la entrega de comida. Los resultados mostraron que la administración crónica tuvo un efecto de mejora temporal en el palanqueo (sign tracking) y el sesgo de respuesta. La nicotina crónica también aumentó la expresión de FosB/DFosB en el núcleo accumbens y la corteza orbitofrontal específicamente en ratas que se sometieron a entrenamiento conductual. Estos hallazgos sugieren que la nicotina puede potenciar los cambios plásticos mediados por el factor de transcripción FosB/DFosB en estructuras cerebrales claves para la saliencia de incentivo. (Texto tomado de la fuente)
dc.description.abstractCurrent research has highlighted the role of associative learning in addiction. Environmental cues associated through pavlovian processes with appetitive stimuli such as a drug can acquire an incentive salience value, becoming more attractive and facilitating drug-seeking behavior and relapse. The assignment of incentive salience can vary according to the phenotype of the subjects (goal trackers or sign trackers). Although for both phenotypes the conditioned stimulus (CS) can acquire predictive value over the unconditioned stimulus, only for the sign trackers the CS acquires incentive salience. Consistently, it has been reported that incentive value of cues associated with natural reinforcers such as food or water can be amplified by nicotine administration. Using 61 male Wistar rats, the present study aimed to evaluate the effects of chronic nicotine administration on the acquisition of an autoshaping task and FosB/DFosB expression in brain areas related to incentive salience. Results showed that chronic administration had a temporary enhancing effect on sign tracking and response bias. Chronic nicotine also increased FosB/DFosB expression in the nucleus accumbens and orbitofrontal cortex specifically for rats undergoing behavioral training. These findings suggest that nicotine may potentiate plastic changes mediated by the FosB/DFosB transcription factor in brain structures important for incentive salience processes.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias Humanas - Maestría en Psicología
dc.publisherDepartamento de Psicología
dc.publisherFacultad de Ciencias Humanas
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsAtribución-NoComercial 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEfectos farmacológicos y comportamentales de la administración crónica de nicotina en una tarea de automoldeamiento
dc.typeTrabajo de grado - Maestría


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