Autoimmune pulmonary proteinosis in a Chilean teenager, a rare aetiology of interstitial lung disease
Boza, M. L.
Interstitial lung disease (ILD) is rare and encompasses a heterogeneous group of diseases, and is even rarer in children than in adults. ILDs compromise more than 100 different entities, including pulmonary alveolar proteinosis (PAP). There are many causes of PAP in children, including surfactant protein gene mutations (SFTPB, SFTPC, ABCA3, TTF-1), GMCSF receptor mutations and antigranulocyte-macrophage colony-stimulating factor autoantibodies. We report a case of a 13-year-old Chilean girl who presented with an 8-month history of progressive exercise intolerance, fatigability and diminished school performance. Physical examination revealed resting tachypnoea, a few basal bilateral inspiratory crackles, and hypoxaemia on minimal exertion. Clinical suspicion and evaluation, including international collaboration, led to the diagnosis of autoimmune PAP and specific therapy for the condition.
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Unknown author (Lippincott, Williams & Wilkins, 2018)
Correction : Molecular diagnosis of Chagas disease in Colombia : Parasitic loads and discrete typing units in patients from acute and chronic phases Hernández, Carolina; Cucunubá, Zulma; Flórez, Carolina; Olivera, Mario; Valencia-Hernandez, Carlos A.; Zambrano, Pilar; León, Cielo; Ramírez, Juan David (2016)Background: The diagnosis of Chagas disease is complex due to the dynamics of parasitemia in the clinical phases of the disease. The molecular tests have been considered promissory because they detect the parasite in all ...
Gonçalves, Marcelo; Pinto Oliveira, Daniel; Oliveira Oya, Edmar; Gonçalves, Andréa