dc.creator | Cobo, Justo | |
dc.creator | Vicentes, Daniel E. | |
dc.creator | Rodríguez, Ricaurte | |
dc.creator | Marchal, Antonio | |
dc.creator | Glidewell, Christopher | |
dc.date.accessioned | 2019-10-10T20:58:50Z | |
dc.date.available | 2019-10-10T20:58:50Z | |
dc.date.created | 2019-10-10T20:58:50Z | |
dc.date.issued | 2018 | |
dc.identifier | Cobo, J., Vicentes, D. E., Rodríguez, R., Marchal, A., & Glidewell, C. (2018). A concise synthesis of a highly substituted 6-(1H-benzimidazol-1-yl)-5-nitrosopyrimidin-2- amine: Synthetic sequence and the molecular and supramolecular structures of one product and two intermediates. Acta Crystallographica Section C: Structural Chemistry, 74, 696-702. doi:10.1107/S2053229618007015 | |
dc.identifier | https://www.scopus.com/search/form.uri?display=basic | |
dc.identifier | 10.1107/S2053229618007015 | |
dc.description.abstract | A concise and efficient synthesis of 6-benzimidazolyl-5-nitrosopyrimidines has been developed using Schiff base-type intermediates derived from N4-(2-aminophenyl)-6-methoxy-5-nitrosopyrimidine-2,4-diamine. 6-Methoxy-N4-{2-[(4-methylbenzylidene)amino]phenyl}-5-nitrosopyrimidine-2,4-diamine, (I), and N4-{2-[(ethoxymethylidene)amino]phenyl}-6-methoxy-5-nitrosopyrimidine-2,4-diamine, (III), both crystallize from dimethyl sulfoxide solution as the 1:1 solvates C19H18N6O2·C2H6OS, (Ia), and C14H16N6O3·C2H6OS, (IIIa), respectively. The interatomic distances in these intermediates indicate significant electronic polarization within the substituted pyrimidine system. In each of (Ia) and (IIIa), intermolecular N-H…O hydrogen bonds generate centrosymmetric four-molecule aggregates. Oxidative ring closure of intermediate (I), effected using ammonium hexanitratocerate(IV), produced 4-methoxy-6-[2-(4-methylphenyl-1H-benzimidazol-1-yl]-5-nitrosopyrimidin-2-amine, C19H16N6O2, (II) [Cobo et al. (2018). Private communication (CCDC 1830889). CCDC, Cambridge, England], where the extent of electronic polarization is much less than in (Ia) and (IIIa). A combination of N–H…N and C–H…O hydrogen bonds links the molecules of (II) into complex sheets. | |
dc.language | eng | |
dc.relation | Acta Crystallographica Section C: Structural Chemistry;Vol.74, 2018 páginas 696-702 | |
dc.rights | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Atribución-CompartirIgual 4.0 Internacional (CC BY-SA 4.0) | |
dc.rights | Derechos Reservados - Universidad de Ciencias Aplicadas y Ambientales | |
dc.source | https://www.scopus.com/search/form.uri?display=basic | |
dc.source | https://www.scopus.com/search/form.uri?display=basic | |
dc.title | A concise synthesis of a highly substituted 6-(1H-benzimidazol-1-yl)-5-nitrosopyrimidin-2- amine: Synthetic sequence and the molecular and supramolecular structures of one product and two intermediates | |
dc.type | Artículo de revista | |