Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
dc.creator | Petermann, Fanny | |
dc.creator | Villagrán, Marcelo | |
dc.creator | Troncoso, Claudia | |
dc.creator | Mardones, Lorena | |
dc.creator | Leiva, Ana María | |
dc.creator | MartÍnez, María Adela | |
dc.creator | Garrido-Méndez, Alex | |
dc.creator | Poblete-Valderrama, Felipe | |
dc.creator | Salas-Bravo, Carlos | |
dc.creator | Ramírez-Vélez, Robinson | |
dc.creator | Arbeláez Ulloa, Natalia | |
dc.creator | Pérez-Bravo, Francisco | |
dc.creator | Celis-Morales, Carlos | |
dc.date.accessioned | 2019-03-07T17:02:39Z | |
dc.date.available | 2019-03-07T17:02:39Z | |
dc.date.created | 2019-03-07T17:02:39Z | |
dc.date.issued | 2018 | |
dc.identifier | 0034-9887 | |
dc.identifier | http://repository.urosario.edu.co/handle/10336/19221 | |
dc.identifier | 10.4067/s0034-98872018000600717 | |
dc.description.abstract | Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors. © 2018, Sociedad Medica de Santiago. All rights reserved. | |
dc.language | spa | |
dc.relation | Revista Medica de Chile, ISSN:3498-87, Vol. 146 (2018) pp. 717-726 | |
dc.relation | https://scielo.conicyt.cl/pdf/rmc/v146n6/0034-9887-rmc-146-06-0717.pdf | |
dc.relation | 726 | |
dc.relation | 717 | |
dc.relation | Revista Medica de Chile | |
dc.relation | Vol. 146 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.rights | Abierto (Texto Completo) | |
dc.source | The Lancet Diabetes E. Should we officially recognise obesity as a disease? (2017) Lancet Diabetes Endocrinol, 5 (7), p. 483 | |
dc.source | instname:Universidad del Rosario | |
dc.source | reponame:Repositorio Institucional EdocUR | |
dc.subject | Alpha Ketoglutarate Dependent Dioxygenase Fto | |
dc.subject | humana | |
dc.subject | Fto Protein | |
dc.subject | Single Nucleotide | |
dc.subject | Human | |
dc.subject | Allele | |
dc.subject | Anthropometry | |
dc.subject | Chile | |
dc.subject | Cross-Sectional Study | |
dc.subject | Ethnology | |
dc.subject | Genetic Marker | |
dc.subject | Genetic Predisposition | |
dc.subject | Genetics | |
dc.subject | Genotype | |
dc.subject | Human | |
dc.subject | Lifestyle | |
dc.subject | Male | |
dc.subject | Obesity | |
dc.subject | Polymerase Chain Reaction | |
dc.subject | Reference Value | |
dc.subject | Risk Factor | |
dc.subject | Single Nucleotide Polymorphism | |
dc.subject | Socioeconomics | |
dc.subject | Statistical Model | |
dc.subject | Young Adult | |
dc.subject | Adiposity | |
dc.subject | Alleles | |
dc.subject | Alpha-Ketoglutarate-Dependent Dioxygenase Fto | |
dc.subject | Anthropometry | |
dc.subject | Chile | |
dc.subject | Cross-Sectional Studies | |
dc.subject | Genetic Markers | |
dc.subject | Genetic Predisposition To Disease | |
dc.subject | Genotype | |
dc.subject | Life Style | |
dc.subject | Linear Models | |
dc.subject | Male | |
dc.subject | Obesity | |
dc.subject | Polymerase Chain Reaction | |
dc.subject | Polymorphism | |
dc.subject | Reference Values | |
dc.subject | Socioeconomic Factors | |
dc.subject | Young Adult | |
dc.subject | Alfa cetoglutarato dependiente dioxigenasa F | |
dc.subject | La proteína FTO | |
dc.subject | Alelo | |
dc.title | Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena | |
dc.type | article |