Artículo de revista
Role of non-coding regulatory RNA in the virulence of human pathogenic vibrios
Fecha
2017Registro en:
Frontiers in Microbiology, January 2017 | Volume 7 | Article 2160
1664302X
10.3389/fmicb.2016.02160
Autor
Pérez Reytor, Diliana
Plaza, Nicolás
Espejo, Romilio T.
Navarrete, Paola
Bastías, Roberto
García, Katherine
Institución
Resumen
In recent decades, the identification of small non-coding RNAs in bacteria has revealed
an important regulatory mechanism of gene expression involved in the response to
environmental signals and to the control of virulence. In the family Vibrionaceae, which
includes several human and animal pathogens, small non-coding RNAs (sRNAs) are
closely related to important processes including metabolism, quorum sensing, virulence,
and fitness. Studies conducted in silico and experiments using microarrays and highthroughput
RNA sequencing have led to the discovery of an unexpected number of
sRNAs in Vibrios. The present review discusses the most relevant reports regarding
the mechanisms of action of sRNAs and their implications in the virulence of the main
human pathogens in the family Vibrionaceae: Vibrio parahaemolyticus, V. vulnificus and
V. cholerae.
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