Artículos de revistas
Impact of estrogens and estrogen receptor-α in brain lipid metabolism
Fecha
2018Registro en:
American Journal of Physiology - Endocrinology and Metabolism, Volumen 315, Issue 1, 2018, Pages E7-E14
15221555
01931849
10.1152/ajpendo.00473.2017
Autor
Morselli, Eugenia
de Souza Santos, Roberta
Gao, Su
Ávalos, Yenniffer
Criollo Céspedes, Alfredo
Palmer, Biff F.
Clegg, Deborah J.
Institución
Resumen
© 2018 American Physiological Society. All rights reserved. Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation through their direct impact on intracellular signaling cascades within the central nervous system.