dc.contributor | Carregaro, Adriano Bonfim | |
dc.contributor | http://lattes.cnpq.br/5041153897534751 | |
dc.contributor | Corte, Flavio Desessards de La | |
dc.contributor | http://lattes.cnpq.br/4040388452531898 | |
dc.contributor | Queiroz Neto, Antonio de | |
dc.contributor | http://lattes.cnpq.br/6695662273447490 | |
dc.creator | Cruz, Fernando Silvério Ferreira da | |
dc.date.accessioned | 2009-03-09 | |
dc.date.available | 2009-03-09 | |
dc.date.created | 2009-03-09 | |
dc.date.issued | 2008-08-08 | |
dc.identifier | CRUZ, Fernando Silvério Ferreira da. Physiological changes and sedative effects of the association between buprenorphine and xylazine in horses. 2008. 78 f. Dissertação (Mestrado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2008. | |
dc.identifier | http://repositorio.ufsm.br/handle/1/8938 | |
dc.description.abstract | The α₂-adrenergic receptor agonists are widely used in equine practice, especially in antalgic
therapy, because they promote profound sedation and moderate visceral analgesia. The
opioids are used in horses with some restriction due to the excitatory effects in this specie.
The objective of this study was to evaluate the sedative effect, hemodynamic, pulmonary and
digestory changes due to the neuroleptoanalgesic association of buprenorphine and different
doses of xylazine. Six adults horses of both gender, weighting an average of 400 Kg. The
animals were control of themselves, being divided into four groups, control group (CG) saline
NaCl 0,9% solution administrated IV, and three other groups with buprenorphine 10 μg/kg
associated to three different doses of xylazine, 0,25 mg/kg (BX25), 0,50 mg/kg (BX50) and
0,75 mg/kg (BX75) IV. Sedative effects, gastrointestinal motility, FC, f, SAP, MAP, DAP,
blood gas tension analysis and core temperature were evaluated 30 min before, immediately
before the administration of any treatment for basal values and after 5, 15 and every 15 min
until 120 min post-treatment. Gastrointestinal motility was evaluated by the same period and
for 12 hours, every 2 hours. Blood samples were collected at 0, 30 and 60 min. Parametric
variables were analyzed with ANOVA, followed by Dunnett test for intra group and Tukey
test between groups. For the non-parametric variable (intestinal motility) Wilcoxon test was
used. Differences was considered significant when P<0.05. Intense sedative effect was
observed in the three groups with the neuroleptoanalgesic association lasting 45 min in BX75
with profound ataxia. Intestinal motility decreased with 5 minutes after administration and
remained decreased for 8 hours. Hemodynamic parameters started to increased after 30 min
and no changes were observed in respiratory frequency and blood gas samples analysis, only
HCO3- showed increase. Synergistic effect was observed, maintaining hemodynamic stability,
with minimal pulmonary effects. The hypomotility observed must be considered when the
association is used in horses with gastrointestinal disorders. | |
dc.publisher | Universidade Federal de Santa Maria | |
dc.publisher | BR | |
dc.publisher | Farmacologia | |
dc.publisher | UFSM | |
dc.publisher | Programa de Pós-Graduação em Farmacologia | |
dc.rights | Acesso Aberto | |
dc.subject | Xilazina | |
dc.subject | Buprenorfina | |
dc.subject | Equinos | |
dc.subject | Sedação | |
dc.subject | Analgesia | |
dc.subject | Xylazine | |
dc.subject | Buprenorphine | |
dc.subject | Horses | |
dc.subject | Sedation | |
dc.subject | Analgesia | |
dc.title | Alterações fisiológicas e efeitos sedativos da associação entre buprenorfina e xilazina em equinos | |
dc.type | Dissertação | |