Artículos de revistas
Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
Date
2017-10-01Registration in:
Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.
0041-0101
10.1016/j.toxicon.2017.08.002
WOS:000411542300025
Author
Univ Fed Ceara
Universidade Estadual Paulista (UNESP)
Univ Fed Rio Grande do Norte
Institutions
Abstract
Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.