Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

Artículos de revistas

Date

2017-10-01

Registration in:

Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.

0041-0101

http://hdl.handle.net/11449/165808

10.1016/j.toxicon.2017.08.002

WOS:000411542300025

http://repositorioslatinoamericanos.uchile.cl/handle/2250/2641702

Author

Univ Fed Ceara

Universidade Estadual Paulista (UNESP)

Univ Fed Rio Grande do Norte

Institutions

Universidade Estadual Paulista (Brasil)

Abstract

Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.

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