Artículos de revistas
Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite
Fecha
2016-01-01Registro en:
Materials Technology. Abingdon: Taylor & Francis Ltd, v. 31, n. 4, p. 241-245, 2016.
1066-7857
10.1179/1753555715Y.0000000048
WOS:000374885600011
WOS000374885600011.pdf
Autor
Univ Liege
Flemish Inst Technol Res VITO
Universidade Estadual Paulista (Unesp)
Katholieke Univ Leuven
Galephar SA
Institución
Resumen
Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective.