Artículos de revistas
Development and validation of the quantitative analysis of cefuroxime sodium in powder for injection by infrared spectroscopy
Fecha
2012Registro en:
Advances in Analytical Chemistry, v. 2, n. 6, p. 80-87, 2012.
2163-2847
10.5923/j.pc.20120201.02
6438813160518299
9881720291571774
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Ceftazidime quantification by the infrared spectroscopy was developed and validated for pharmaceutical preparations in powder for injection. This method involved absorbance measurements of the band corresponding to aromatic ring centered by 1475-1600 cm-1. Selectivity, linearity, precision and accuracy were determined in order to validate the proposed method. It was also found that the excipient did not interfere with the assay. Calibration curve was obtained for ceftazidime at 0.5 to 7.0 mg, and mean recovery percentage was 98.98 ± 0.70. The proposed method was successfully applied to the assay of ceftazidime in powder for injection.