dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUS Environmental Protection Agency
dc.date.accessioned2015-12-07T15:30:42Z
dc.date.available2015-12-07T15:30:42Z
dc.date.created2015-12-07T15:30:42Z
dc.date.issued2014
dc.identifierSpermatogenesis, v. 4, n. 2, p. 1-12, 2014.
dc.identifier2156-5554
dc.identifierhttp://hdl.handle.net/11449/130996
dc.identifier10.4161/21565562.2014.979114
dc.identifier6326450271169741
dc.identifier26413396
dc.identifierPMC4581052
dc.description.abstractWhile most of this Special Issue is devoted to the testis (which is where most drug and chemically induced toxicity of the male reproductive tract is identified), being able to recognize and understand the potential effects of toxicants on the epididymis is immensely important and an area that is often overlooked. The epididymis is the organ where the post-testicular sperm differentiation occurs, through a complex and still not completely understood sperm maturation process, allowing them to fertilize the oocyte. Also in the epididymis, sperm are stored until ejaculation, while being protected from immunogenic reaction by a blood-epididymis barrier. From a toxicologic perspective the epididymis is inherently complicated as its structure and function can be altered both indirectly and directly. In this review we will discuss the factors that must be considered when attempting to distinguish between indirect and direct epididymal toxicity and highlight what is currently known about mechanisms of epididymal toxicants, using the rat as a reference model. We identify 2 distinguishable signature lesions - one representing androgen deprivation (secondary to Leydig cell toxicity in the testis) and another representing a direct acting toxicant. Other commonly observed alterations will also be shown and discussed. Finally, we point out that many of the key functions of the epididymis can be altered in the absence of a detectable change in tissue structure. Collectively, we hope this will provide pathologists with increased confidence in identification of epididymal toxicity and enable more informed guidance as mechanism of action is considered.
dc.languageeng
dc.relationSpermatogenesis
dc.relation0,128
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectAndrogen
dc.subjectEpididymis
dc.subjectHistopathology
dc.subjectSperm maturation
dc.subjectToxicity
dc.titleInterpreting histopathology in the epididymis
dc.typeArtículos de revistas


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