Artículos de revistas
Pamidronate attenuates diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning
Fecha
2015-01-01Registro en:
Cellular Physiology And Biochemistry. Basel: Karger, v. 35, n. 1, p. 259-269, 2015.
1015-8987
10.1159/000369693
WOS:000348048000024
WOS000348048000024.pdf
1590971576309420
4463138671998432
5016839015394547
1213140801402647
7438704034471673
0000-0002-5843-6232
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Background/Aims: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Methods: Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Results: Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins. Conclusion: Pamidronate attenuates diastolic dysfunction following MI.