Artículos de revistas
Neuronal excitability level transition induced by electrical stimulation
Fecha
2014-12-01Registro en:
European Physical Journal-special Topics. Heidelberg: Springer Heidelberg, v. 223, n. 13, p. 2913-2922, 2014.
1951-6355
10.1140/epjst/e2014-02304-x
WOS:000346248900022
Autor
Universidade de São Paulo (USP)
Humboldt Univ
Potsdam Inst Climate Impact Res
Hosp Israelita Albert Einstein
Universidade Estadual Paulista (Unesp)
Institución
Resumen
In experimental studies, electrical stimulation (ES) has been applied to induce neuronal activity or to disrupt pathological patterns. Nevertheless, the underlying mechanisms of these activity pattern transitions are not clear. To study these phenomena, we simulated a model of the hippocampal region CA1. The computational simulations using different amplitude levels and duration of ES revealed three states of neuronal excitability: burst-firing mode, depolarization block and spreading depression wave. We used the bifurcation theory to analyse the interference of ES in the cellular excitability and the neuronal dynamics. Understanding this process would help to improve the ES techniques to control some neurological disorders.