Artículos de revistas
Ventricular systolic reserve in asymptomatic children previously treated with low doses of anthracyclines: A longitudinal, prospective exercise echocardiography study
Pediatric Blood and Cancer, v. 59, n. 3, p. 548-552, 2012.
Faculdade de Medicina de Marília (FAMEMA)
Universidade Estadual Paulista (UNESP)
Background: The time course of mild cardiotoxicity induced by anthracycline remains unknown. The aim of this study was to evaluate the long-term evolution of decreased myocardial reserve in children previously treated with a cumulative dose of anthracycline up to 100mg/m 2. Patients and Methods: Twenty-seven asymptomatic cancer survival patients (25 with lymphoblastic leukemia), in continuous remission and off treatment for >12 months with no alterations in conventional echocardiograms were evaluated by exercise echocardiography at 37±15.4 months (T1) and 101±24 months (T2) after finishing treatment (ADRIA group). This group was compared with 25 healthy individuals (control group) similar to the ADRIA group with respect to age and body surface area (BSA). All individuals underwent treadmill exercise testing according to Bruce protocol. Echocardiograms were performed before and immediately after exercise. Results: The groups were similar regarding cardiac structure and left ventricular (LV) systolic function at rest at T1 and T2. The growth of LV posterior wall thickness related to BSA was lower in the ADRIA group at T2. Post exercise, smaller LV ejection indexes and attenuated changes in the afterload in ADRIA group were observed at T1 and T2. Conclusion: The decreased systolic reserve induced by a low dose of anthracycline in asymptomatic children and adolescents remains unaffected over a 5-year period, suggesting that positive outcomes in chronic cardiotoxicity would be expected in patients with mild impairment after anthracycline treatment. © 2011 Wiley Periodicals, Inc.
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Ventricular systolic reserve in asymptomatic children previously treated with low doses of anthracyclines: A longitudinal, prospective exercise echocardiography study Guimaraes-Filho, Fabio V.; Tan, Doralice M.; Braga, Joao C.F.; Rodrigues, Alexandre; Waib, Paulo H.; Matsubara, Beatriz Bojikian
Food restriction-induced myocardial dysfunction demonstrated by the combination of in vivo and in vitro studies Okoshi, Katashi; Matsubara, Luiz Shiguero; Okoshi, Marina Politi; Cicogna, Antonio Carlos; Fioretto, José Roberto; Padovani, Carlos Roberto; Aragon, Flávio F; Matsubara, Beatriz Bojikian
Food restriction-induced myocardial dysfunction demonstrated by the combination of in vivo and in vitro studies Universidade Estadual Paulista (UNESP) (2002-11-01)The aim of this study was to test the hypothesis that protein-calorie undernutrition decreases myocardial contractility jeopardizing ventricular function, and that ventricular dysfunction can be detected noninvasively. ...