Artículos de revistas
Head and neck carcinogenesis: Impact of MTHFD1 G1958A polymorphism
Fecha
2011-03-01Registro en:
Revista da Associacao Medica Brasileira, v. 57, n. 2, p. 188-193, 2011.
0104-4230
10.1016/S2255-4823(11)70043-1
2-s2.0-79955739445
2-s2.0-79955739445.pdf
Autor
Faculdade de Medicina de São José do Rio Preto (FAMERP)
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer, and to find the association of the polymorphism with the risk factors and clinical and histopathological characteristics. Methods: Retrospective study investigating MTHFD1 G1958A polymorphism in 694 subjects (240 patients in the Case Group and 454 in the Control Group) by Restriction Fragment Length Polymorphism (RFLP) Analysis. Multiple logistic regression and chi-square tests were used in the statistical analysis. Results: Multivariable analysis showed that smoking and age over 42 years were disease predictors (p < 0.05). MTHFD1 1958GA or AA genotypes were associated with smoking (p = 0.04) and alcoholism (p = 0.03) and were more ofen found in more advanced stage tumors (p = 0.04) and in patients with a shorter survival (p = 0.03). Conclusion: Te presence of MTHFD1 G1948A polymorphism associated with smoking and alcoholism raises the head and neck cancer risk.