Brazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developments

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:24:46Z
dc.date.available2014-05-27T11:24:46Z
dc.date.created2014-05-27T11:24:46Z
dc.date.issued2010-08-25
dc.identifierAsian Pacific Journal of Cancer Prevention, v. 11, n. 1, p. 7-8, 2010.
dc.identifier1513-7368
dc.identifierhttp://hdl.handle.net/11449/71833
dc.identifier2-s2.0-77955810808
dc.identifier2-s2.0-77955810808.pdf
dc.description.abstractIn 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. The protocol adopted by IBAMA was a modification of the one originally proposed by researchers led by Nobuyuki Ito, from the Nagoya City University Medical School. Among the modifications established in the Brazilian protocol were the use of both sexes of the outbreed Wistar strain of rats and two positive control test chemicals. The adoption of the modified DMBDD protocol was instrumental during the last decade for qualifying technical people and to spread knowledge on chemical carcinogenesis in Brazil.
dc.languageeng
dc.relationAsian Pacific Journal of Cancer Prevention
dc.relation0,616
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectCell proliferation
dc.subjectEstrogen
dc.subjectImmunosuppression
dc.subjectMutagen/carcinogen screening
dc.subjectTwo-year bioassay
dc.subjectcarcinogen
dc.subjectanimal
dc.subjectantibody specificity
dc.subjectbioassay
dc.subjectBrazil
dc.subjectcarcinogen testing
dc.subjectchemically induced disorder
dc.subjectconference paper
dc.subjectdrug effect
dc.subjectexperimental neoplasm
dc.subjectfemale
dc.subjectFischer 344 rat
dc.subjectgovernment regulation
dc.subjectmale
dc.subjectpathology
dc.subjectrat
dc.subjectstandard
dc.subjectAnimals
dc.subjectBiological Assay
dc.subjectCarcinogenicity Tests
dc.subjectCarcinogens
dc.subjectFemale
dc.subjectGovernment Regulation
dc.subjectMale
dc.subjectNeoplasms, Experimental
dc.subjectOrgan Specificity
dc.subjectRats
dc.subjectRats, Inbred F344
dc.titleBrazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developments
dc.typeActas de congresos


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