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Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle
Case Reports and Clinical Practice Review, v. 16, n. 8, 2010.
Universidade Estadual Paulista (UNESP)
Background: The aim of this study was to analyze stable hypertrophied myocardial function and its response to inotropic maneuvers in rats submitted to renovascular hypertension for a 10-week period (RHT group, n=10). Material/Methods: Myocardial performance was studied in isolated left ventricle papillary muscles in isometric contraction under the following conditions: at postrest contraction of 30 seconds (PRC), at extracellular calcium (ECa 2+) chloride concentration of 1.25 and 5.20 mM, and after beta-adrenergic stimulation with 10 -6 M isoproterenol (ISOP). Results: The results were compared with normotensive Wistar controls rats (C group, n=10). In basal condition, resting tension, and contraction time (TPT) were greater, while relaxation time (RT 50) tended to be longer in RHT than C group. PRC and ISOP promoted a similar change in muscle function response intensity (Δ) in both groups. ECa 2+ shift did not change TPT in the C group and decreased TPT in the RHT animals; Δ was different between these groups. RT 50 increased in C and decreased in RHT, both without statistical significance; however, Δ was different. Conclusions: These results suggest that hypertrophied myocardial dysfunction may be attibuted to changes in intracellular calcium cycling. © Med Sci Monit, 2010.
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Hypertrophied myocardium is more dependent on extracellular calcium than the normal cardiac muscle de Barros, Reginaldo; Zornoff, Leonardo Antonio Mamede; Ribeiro, Henrique B.; Okoshi, Marina Politi; Padovani, Carlos Roberto; Aragon, Flávio F.; Cicogna, Antonio Carlos
A administração precoce de hormônio de crescimento resulta em efeitos deletérios na remodelação ventricular após o infarto agudo do miocárdio Mill, José G.; Zornoff, Leonardo A. M.; Okoshi, Marina P.; Okoshi, Katashi; Padovani, Carlos R.; Sugisaki, Mário; Leite, Cláudia M.; Cicogna, Antônio C.
A administração precoce de hormônio de crescimento resulta em efeitos deletérios na remodelação ventricular após o infarto agudo do miocárdio Universidade Federal do Espírito Santo (UFES); Universidade Estadual Paulista (UNESP) (2005-02-01)Objective: To assess the effect of growth hormone (GH) on myocardial remodeling in infarcted rats. Methods: This study comprised 24 Wistar rats divided into 3 groups as follows: 1) AMI-GH group - comprising 8 rats that ...