Artículos de revistas
Food restriction-induced myocardial dysfunction demonstrated by the combination of in vivo and in vitro studies
Nutrition Research, v. 22, n. 11, p. 1353-1364, 2002.
Universidade Estadual Paulista (UNESP)
The aim of this study was to test the hypothesis that protein-calorie undernutrition decreases myocardial contractility jeopardizing ventricular function, and that ventricular dysfunction can be detected noninvasively. Five-month-old male Wistar-Kyoto rats were fed with regular rat chow ad libitum for 90 days (Control group, n = 14). A second group of rats received 50% of the amount of diet consumed by de control group (Food restricted group, n = 14). Global LV systolic function was evaluated in vivo, noninvasively, by transthoracic echocardiogram. After echocardiographic study, myocardial contractility was assessed in vitro in the isovolumetrically beating isolated heart in eight animals from each group (Langendorff preparation). The in vivo LV fractional shortening showed that food restriction depressed LV systolic function (p < 0.05). Myocardial contractility was impaired as assessed by the maximal rate of rise of LV pressure (+dP/dt), and developed pressure at diastolic pressure of 25 mmHg (p < 0.05). Furthermore, food restriction induced eccentric ventricular remodeling, and reduced myocardial elasticity and LV compliance (p < 0.05). In conclusion, food restriction causes systolic dysfunction probably due to myocardial contractility impairment and reduction of myocardial elasticity. © 2002 Elsevier B.V. All rights reserved.
Showing items related by title, author, creator and subject.
Soriano, Eline A.; Gaiolla, Paula Schmidt Azevedo; Miot, Hélio Amante; Minicucci, Marcos Ferreira; Pansani, Mariele C.; Matsubara, Luiz Shiguero; Okoshi, Katashi; Zornoff, Leonardo Antonio Mamede; Matsubara, Beatriz Bojikian; Paiva, Sergio A.R.
Universidade Estadual Paulista (UNESP) (2013-02-10)Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...
Waist circumference, but not body mass index, is a predictor of ventricular remodeling after anterior myocardial infarction Cogni, Ana Lucia; Farah, Elaine; Minicucci, Marcos Ferreira; Gaiolla, Paula Schmidt Azevedo; Okoshi, Katashi; Matsubara, Beatriz Bojikian; Zanati, Silméia G.; Paiva, Sergio A.R.; Zornoff, Leonardo Antonio Mamede