Artículos de revistas
Retinoic acid prevents ventricular remodelling induced by tobacco smoke exposure in rats
Fecha
2011-02-01Registro en:
Acta Cardiologica. Brussels: Acta Cardiologica, v. 66, n. 1, p. 3-7, 2011.
0001-5385
10.2143/AC.66.1.2064960
WOS:000287980400002
6309835137998766
6990977122340795
5016839015394547
1213140801402647
7438704034471673
0000-0002-5843-6232
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Objective Our objective was to test the hypothesis that retinoic acid supplementation could attenuate ventricular remodelling induced by tobacco smoke exposure in rats.Methods and results Wistar rats were allocated into three groups: control (C, n = 8); exposed to tobacco smoke (ETS, n = 9); exposed to tobacco smoke and all-trans-retinoic acid (ETS-RA, n = 9). After two months, cardiac function and geometry were assessed by echocardiography, and geometry changes were confirmed by morphometric analysis. Data are expressed as mean +/- SD or medians (including the lower quartile and upper quartile). ETS showed higher normalized left ventricular diastolic diameters than groups C and ETS-RA (C = 18.4 +/- 3.57 mm/kg, ETS = 23.0 +/- 1.8, ETS-RA = 19.5 +/- 0.99; P < 0.05) and systolic diameters (C = 8.25 +/- 2.16 mm/kg, ETS = 11.5 +/- 1.31, ETS-RA = 8.25 +/- 0.71 mm/kg; P < 0.05). ETS showed reduced ejection fraction (C = 91 +/- 2.0, ETS = 87 +/- 3.0, ETS-RA = 92 +/- 3.0; P < 0.05) and fractional shortening (C = 55.8 +/- 4.41 %, ETS = 49.7 +/- 4.43 %, ETS-RA = 57.6 +/- 5.15 %; P = 0.01) compared to C and ETS-RA. ETS had increased myocyte cross-sectional area (C = 294 +/- 21 mm2, ETS = 352 +/- 44, ETS-RA = 310 +/- 35; P < 0.05) compared to C and ETS-RA. Considering all variables, there were no differences between groups C and ETS-RA.Conclusion Retinoic acid prevented ventricular remodelling induced by tobacco smoke exposure.