Artículos de revistas
Synthesis, characterization and antimycobacterial activity of Ag(I)-aspartame, Ag(I)-saccharin and Ag(I)-cyclamate complexes
Fecha
2007-10-01Registro en:
Archiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 340, n. 10, p. 538-542, 2007.
0365-6233
10.1002/ardp.200700040
WOS:000250488600005
Autor
Universidade Estadual Paulista (Unesp)
Instituto Adolfo Lutz (IAL)
Institución
Resumen
The present work describes the synthesis and antimycobacterial activity of three Ag(I)-complexes with the sweeteners aspartame, saccharin, and cyclamate as ligands, with the aim of finding new candidate substances for fighting tuberculosis and other mycobacterial infections. The minimal inhibitory concentration of these three complexes was investigated in order to determine their in-vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium malmoense, and Mycobacterium kansasii. The MIC values were determined using the Microplate Alamar Blue Assay. The best MIC values found for the complexes were 9.75 mu M for Ag(l)-aspartame against M. kansasii and 15.7 mu M for Ag(I)-cyclamate against M. tuberculosis.