Artículos de revistas
Praziquantel-loaded PLGA nanoparticles: preparation and characterization
Fecha
2005-02-01Registro en:
Journal of Microencapsulation. Abingdon: Taylor & Francis Ltd, v. 22, n. 1, p. 13-24, 2005.
0265-2048
10.1080/02652040400026285
WOS:000229478600002
Autor
Universidade Estadual Paulista (Unesp)
Institución
Resumen
Nanoparticles containing praziquantel made of Poly (D,L-lactide-co-glycolide) were designed by an emulsion-solvent evaporation method. Two organic solvents were separately utilized as disperse phase: methylene chloride and ethyl acetate. The size of the particles prepared with the former solvent was bigger than the particles prepared with the latter. The entrapment efficiency was bigger when methylene chloride was used, 79.82% in comparison with 29.27% by using ethyl acetate. DSC and infrared studies showed that no strong chemical interaction between drug and polymer occurred. Release kinetics of praziquantel, used as a model drug, was governed not only by actual drug loading but also by particles size. The higher the drug content and the smaller the particle size resulted in faster drug release.