Artículos de revistas
High CD8+ and absence of Foxp3+ T lymphocytes infiltration in gallbladder tumors correlate with prolonged patients survival
Fecha
2018Registro en:
BMC Cancer, Volumen 18, Issue 1, 2018,
14712407
10.1186/s12885-018-4147-6
Autor
Fluxá Rojas, Paula
Rojas Sepúlveda, Daniel
Gleisner Muñoz, María Alejandra
Tittarelli, Andrés
Villegas, Pablo
Tapia, Loreto
Rivera, María Teresa
López, Mercedes Natalia
Catán, Felipe
Uribe, Mario
Salazar Onfray, Flavio
Institución
Resumen
© 2018 The Author(s). Background: Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only effective treatment, and a five-year survival rate of advanced-stage patients is less than 10%. Hence, exploring immunotherapy is relevant, although GBC immunogenicity is poorly understood. This study examined the relationship between the host immune response and GBC patient survival based on the presence of tumor-infiltrating lymphocytes at different disease stages. Methods: Tumor tissues from 80 GBC patients were analyzed by immunohistochemistry for the presence of CD3+, CD4+, CD8+, and Foxp3+ T cell populations, and the results were associated with clinical stage and patient survival. Results: The majority of tumor samples showed CD3+ T cell infiltration, which correlated with better prognosis, particularly in advanced disease stages. CD8+, but no