Artículo de revista
Positron Emission Tomography/Computed Tomography Assessment After Immunochemotherapy and Irradiation Using the Lugano Classification Criteria in the IELSG-26 Study of Primary Mediastinal B-Cell Lymphoma
Fecha
2017Registro en:
International Journal of Radiation Oncology Biology Physics, Volumen 97, Issue 1, 2018, Pages 42-49
1879355X
03603016
10.1016/j.ijrobp.2016.09.031
Autor
Ceriani, Luca
Martelli, Maurizio
Gospodarowicz, Maria K.
Ricardi, Umberto
Ferreri, Andrés J.M.
Chiappella, Annalisa
Stelitano, Caterina
Balzarotti, Monica
Cabrera, Maria E.
Cunningham, David
Guarini, Attilio
Zinzani, Pier Luigi
Giovanella, Luca
Johnson, P
Institución
Resumen
© 2016 Elsevier Inc. Purpose To assess the predictive value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for disease recurrence after immunochemotherapy (R-CHT) and mediastinal irradiation (RT), using the recently published criteria of the Lugano classification to predict outcomes for patients with primary mediastinal large B-cell lymphoma. Methods and Materials Among 125 patients prospectively enrolled in the IELSG-26 study, 88 were eligible for central review of PET/CT scans after completion of RT. Responses were evaluated using the 5-point Deauville scale at the end of induction R-CHT and after consolidation RT. According to the Lugano classification, a complete metabolic response (CMR) was defined by a Deauville score (DS) ≤3. Results The CMR (DS1, -2, or -3) rate increased from 74% (65 patients) after R-CHT to 89% (78 patients) after consolidation RT. Among the 10 patients (11%) with persistently positive scans, the residual uptake after RT w