Artículo de revista
Changes in regional cerebral blood flow are associated with endothelial dysfunction markers in cocaine-dependent patients under recent abstinence
Fecha
2015Registro en:
Journal of Addiction Medicine, Volumen 9, Issue 2, 2018, Pages 139-146
19353227
19320620
10.1097/ADM.0000000000000109
Autor
Massardo, Teresa
Quintana, Juan C.
Jaimovich, Rodrigo
Sáez, Claudia G.
Cabreras, Manuel J.
Pereira-Flores, Karla
Ibáñez, Carlos
Pallavicini, Julio
Véliz, Jonathan
Mezzano, Diego
Pereira, Jaime
Institución
Resumen
© 2015 American Society of Addiction Medicine. Objectives: Cocaine is a known risk factor for several vascular ischemic events. The underlying mechanisms leading to the complications are not fully understood, although thrombus formation and accelerated atherosclerosis are prominent findings. Evidence of endothelial dysfunction (ED), a key phenomenon in the pathogenesis of atherogenesis, has been demonstrated in cocaine-dependent individuals. Abnormal regional cerebral blood flow (rCBF) is a common finding among chronic cocaine users. The aim of this study was to evaluate whether brain perfusion changes were associated with ED markers in cocaine-dependent individuals. Methods: Circulating endothelial cells (CECs), soluble intercellular cell adhesion molecule, and the chemokine regulated on activation normal T cells expressed and secreted were measured in 27 DSM-IV (Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition) cocaine-dependents patients. Regional cerebral blood