Artículos de revistas
ER-to-mitochondria miscommunication and metabolic diseases
Fecha
2015Registro en:
Biochimica et Biophysica Acta - Molecular Basis of Disease, Volumen 1852, Issue 10, 2018, Pages 2096-2105
1879260X
09254439
10.1016/j.bbadis.2015.07.011
Autor
López Crisosto, Camila
Bravo Sagua, Roberto
Rodríguez Peña, Marcelo
Mera, Claudia
Castro, Pablo F.
Quest, Andrew F. G.
Rothermel, Beverly A.
Cifuentes, Mariana
Lavandero González, Sergio
Institución
Resumen
© 2015 Elsevier B.V.. Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic system of communication must exist between the various compartments. Direct endoplasmic reticulum (ER)-mitochondria communication is facilitated by the physical interaction of their membranes in dedicated structural domains known as mitochondria-associated membranes (MAMs), which facilitate calcium (Ca<sup>2+</sup>) and lipid transfer between organelles and also act as platforms for signaling. Numerous studies have demonstrated the importance of MAM in ensuring correct function of both organelles, and recently MAMs have been implicated in the genesis of various human diseases. Here, we review the salient structural features of interorganellar communication via MAM and discuss the most common experimental techniques employed to assess functionality of these domains. Fina