Artículo de revista
The identification of two subgroups of obese women with differing endometrial proliferation levels: Potential consequences in the development of endometrial cancer
Fecha
2012Registro en:
International Journal of Obesity, Volumen 36, Issue 7, 2018, Pages 1012-1015
03070565
14765497
10.1038/ijo.2011.189
Autor
Villavicencio, A.
Aguilar, G.
Acũa, J.
Gabler Neale, Fernando
Soto, E.
Gaete, F.
Pẽaloza, P.
Celis, M.
Owen, G. I.
Institución
Resumen
Enhanced endometrial proliferation correlates obesity to type-I (estrogen-dependent) endometrial cancer (EC). Our aim was to distinguish obese women (without EC) with differing endometrial proliferation. Endometrial and blood samples were obtained from normal-weight and obese women without EC. Type-I EC samples were obtained from obese patients. On measuring endometrial proliferation (Ki67 and phosphorylated histone H3 (p-H3)), two groups of obese women without EC were identified: obeseHigh Proliferating (O HP) and obeseLow Proliferating (OLP). Increased Ki67 (88.5%, P<0.001), p-H3 (62.6%, P<0.01), 17Β-estradiol/ progesterone ratio (46.3%, P<0.01) and endometrial estrogen receptor alpha (ERα) (82.2%, P<0.001) were observed in OHP compared with OLP patients. ECs possessed similar ERα and enhanced proliferation as OHP, suggesting that OHP women are at higher risk of type-I EC. OLP women were indistinguishable from normal-weight women regarding these determinants of endometrial proliferat