Artículos de revistas
Metabolic syndrome in children born small-for-gestational age Síndrome metabólica em crianças nascidas pequenas para a idade gestacional
Fecha
2011Registro en:
Arquivos Brasileiros de Endocrinologia e Metabologia, Volumen 55, Issue 8, 2018, Pages 583-589
00042730
16779487
10.1590/S0004-27302011000800012
Autor
Hernández, María Isabel
Mericq, Verónica
Institución
Resumen
Being born small-for-gestational age and a rapid increase in weight during early childhood and infancy has been strongly linked with chronic diseases, including metabolic syndrome, which has been related to intrauterine life environment and linked to epigenetic fetal programming. Metabolic syndrome includes waist circumference ≥ 90 th percentile for age, sex and race, higher levels of blood pressure, triglycerides and fasting glucose, and low levels of HDL-cholesterol. Insulin resistance may be present as early as 1 year of age, and obesity and/or type 2 diabetes are more prevalent in those born SGA than those born AGA. The programming of adaptive responses in children born SGA includes an association with increased blood pressure, changes in endothelial function, arterial properties and coronary disease. Early interventions should be directed to appropriate maternal nutrition, before and during pregnancy, promotion of breast feeding, and prevention of rapid weight gain during infancy,