Artículo de revista
Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia card
Fecha
2010Registro en:
Revista Medica de Chile, Volumen 138, Issue 12, 2018, Pages 1475-1479
00349887
07176163
Autor
Winter, José Luis
Castro, Pablo
Meneses, Luis
Chalhub, Mónica
Verdejo, Hugo
Greig, Douglas
Gabrielli, Luigi
Chiong Lay, Mario
Concepción, Roberto
Mellado, Rosemarie
Hernández, Claudia
Uribe, Sergio
Lavandero González, Sergio
Institución
Resumen
Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HF. Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 ± 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: