Artículos de revistas
Antinociceptive effects of morphine, fentanyl, tramadol and their combination, in morphine-tolerant mice
Fecha
2010Registro en:
Pharmacology Biochemistry and Behavior, Volumen 97, Issue 2, 2018, Pages 363-369
00913057
10.1016/j.pbb.2010.09.005
Autor
Romero, Asunción
Miranda, Hugo F.
Puig, Margarita M.
Institución
Resumen
The development of morphine-tolerance after chronic administration, reduces analgesic efficacy and is a significant clinical problem in some patients; may be managed clinically by increasing the doses of morphine and/or the administration of a second mu-opioid agonist. In morphine-tolerant mice, we investigated the presence of an interaction when two opioids are administered simultaneously. We determined the antinociceptive effects of morphine (M), fentanyl (FEN), and tramadol (TRM) individually and combined in a 1:1 proportion, based on their potency. Nociceptive thresholds were evaluated in CD1 mice using the hot plate test. Morphine tolerance was induced by the subcutaneous implantation of a 75mg morphine pellet, whereas control animals received a placebo pellet; the experiments were performed three days later. In both (placebo and morphine pellets), dose-response curves for M, FEN and TRM, individually and combined were obtained, and the doses that produced 50% inhibition (ED50) we