Artículo de revista
Genetic susceptibility to Andes Hantavirus: Association between severity of disease and HLA alleles in Chilean patients Susceptibilidad genética a hantavirus Andes: Asociación entre la expresión clínica de la infección y alelos del sistema HLA en paciente
Fecha
2007Registro en:
Revista Chilena de Infectologia, Volumen 24, Issue 5, 2018, Pages 351-359
07161018
Autor
Ferrer C., Pablo
Vial C., Pablo A.
Ferrés, Marcela
Godoy M., Paula
Cuiza V., Analia
Marco C., Claudia
Castillo H., Constanza
Umaña C., María Elena
Rothhammer Engel, Francisco
Llop Romero, Elena
Institución
Resumen
Andes hantavirus (ANDV) infection in Chile has a variable clinical expression, and infected individuals may present with different grades of disease severity. This study aimed to determine if clinical expression of ANDV infection in Chilean patients is associated with the HLA system. HLA alleles A, B, DRB1 and DQB1, were studied in two groups of patients with confirmed ANDV infection: 41 patients with a mild disease course (without respiratory failure and cardiovascular shock) and 46 patients with a severe disease course (with respiratory failure and shock). Molecular typing of HLA system was performed by SSP-PCR. The HLA-DRB1*15 allele, was significantly more common in the group of patients with mild disease (p = 0,007) and thus for possibly associated with a protective effect against ANDV infection. Conversely, HLA-B*08 was more common in patients with severe disease (p = 0,06). Although the association was marginally significant, allele HLA-B*08 may be linked to an increased suscept