Artículo de revista
Prevalence of metronidazole, clarithromycin and tetracycline resistance in Helicobacter pylori isolated from Chilean patients Prevalencia de la resistencia a metronidazol, claritromicina y tetraciclina en Helicobacter pylori aislado de pacientes de la reg
Fecha
2007Registro en:
Revista Medica de Chile, Volumen 135, Issue 3, 2018, Pages 287-293
00349887
07176163
Autor
Vallejos M, Cristian
Garrido O, Leonardo
Cáceres L, Dante
Madrid, Ana María
Defilippi, Claudia
Defilippi C, Carlos
Toledo A, Héctor
Institución
Resumen
Background: Helicobacter pylori is a pathogenic bacterium that infects a significant number of individuals. At present, therapeutic strategies to eradicate this bacterium depend on our knowledge of its resistance to antimicrobials. Aims: To evaluate the primary resistance of H pylori to metronidazole (Mtz), clarithromycin (Cla), and tetracycline (Tet) in symptomatic out-patients. Material and Methods: Fifty independent isolates of H pylori were obtained by endoscopy-assisted gastric biopsy from patients attending the University of Chile Clinical Hospital, that previously had not been treated with an eradication regime against this bacterium. The minimal inhibitory concentration of each antimicrobial was determined by agar dilution method. Results: Forty five and 27% of the isolates were found to be resistant to Mtz and Tet, respectively; the majority of these resistant isolates were from patients older than 21 years. Twenty percent of isolates were resistant to Cla; these were distribu