Artículos de revistas
A comparative study of some combined treatment regimens in acute toxoplasmosis in mice
Fecha
1978Registro en:
American Journal of Tropical Medicine and Hygiene, Volumen 27, Issue 4, 2018, Pages 747-750
00029637
10.4269/ajtmh.1978.27.747
Autor
Thiermann, E.
Apt Baruch, Werner
Atías, Antonio
Lorca, M.
Olguín, J.
Institución
Resumen
The effectiveness of five treatment regimens was compared in mice during acute and late infection with Toxoplasma gondii. Parasitic cure rates, as judged by failure of brain tissue from surviving mice to produce infection when inoculated into clean mice, were as follows: pyrimethamine + sulfamethoxypyridazine, 92%; clindamycin + sulfamethoxypyridazine, 75%; spiramycin + sulfamethoxypyridazine, 16.7%; trimethoprim + sulfamethoxazole, 16.7%; sulfamethoxypyridazine alone, 0%. Pyrimethamine + sulfamethoxypyridazine was the most effective combination against acute toxoplasmosis in mice.