Artículo de revista
Discordant clinical presentation and outcome in infant twins sharing a common clonal leukaemia
Fecha
1996Registro en:
British Journal of Haematology, Volumen 93, Issue 1, 2018, Pages 166-169
00071048
10.1046/j.1365-2141.1996.455999.x
Autor
Campbell, Myriam
Cabrera, Maria Elena
Legues, Maria Eugenia
Ridge, Susan
Greaves, Mel
Institución
Resumen
We report the different presentation features and clinical outcome between two identical infant twins with acute lymphoblastic leukaemia with a shared clonal disease and MLL gene rearrangement. One twin relapsed and died, but the other is in complete remission > 4 years after diagnosis. These data, and similar observations on other twin infants with leukaemia, suggest that despite a common clonal in utero, post-natally these leukaemias can evolve independently, at different rates, in the twinned individuals, and that the usually fatal leukaemia associated with t(4;11) MLL gene rearrangement can be effectively treated when the leukaemic burden is small.