dc.creator | Yáñez, C. | |
dc.creator | Núñez Vergara, Luis | |
dc.creator | Squella Serrano, Juan | |
dc.date.accessioned | 2018-12-20T15:20:41Z | |
dc.date.available | 2018-12-20T15:20:41Z | |
dc.date.created | 2018-12-20T15:20:41Z | |
dc.date.issued | 2003 | |
dc.identifier | Electroanalysis, Volumen 15, Issue 22, 2003, Pages 1771-1777 | |
dc.identifier | 10400397 | |
dc.identifier | 10.1002/elan.200302720 | |
dc.identifier | https://repositorio.uchile.cl/handle/2250/158866 | |
dc.description.abstract | The formation of inclusion complexes of well-known 1,4-dihydropyridine calcium antagonists, such as nifedipine (NF) and nicardipine (NC), with beta-cyclodextrin (betaCD) was investigated by differential pulse polarography (DPP) and UV-vis spectrophotometry. The equimolar variation method indicated the formation of the NF-betaCD (1:1, M:M) and a NC-betaCD (1:1, M:M) inclusion complexes. Titrations using the DPP peak currents for NF and NC permitted one to determine formation constant values of (135 +/- 20) M-1 and (357 41) M-1 for NF-betaCD and NC-betaCD, respectively. For comparative purposes we have also applied phase solubility studies with spectrophotometric detection obtaining formation constant values of (129 +/- 5) M-1 and (385 +/- 19) M-1 for NF-betaCD and NC-betaCD, respectively. According to the DPP studies, we can postulate that the inclusion moiety were the nitroaromatic group, in the case of NF-betaCD, and the phenyl group on 3-position of the 1,4-DHP, in the case of NC-betaCD. The solubility of NF in water was increased about three times due to the formation of an inclusion complex with betaCD. For NC the solubility was increased almost seven times. | |
dc.language | en | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
dc.source | Electroanalysis | |
dc.subject | β-Cyclodextrin | |
dc.subject | Differential pulse polarography | |
dc.subject | Inclusion complexes | |
dc.subject | Nicardipine | |
dc.subject | Nifedipine | |
dc.title | Differential pulse polarographic and UV-vis spectrophotometric study of inclusion complexes formed by 1,4-dihydropyridine calcium antagonists, nifedipine and nicardipine with β-cyclodextrin | |
dc.type | Artículo de revista | |