Artículo de revista
Microsomal and peroxisomal fatty acid oxidation in liver of rats with bile duct ligation and two-thirds hepatectomy
Fecha
1997Registro en:
Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Volumen 116, Issue 1, 2018, Pages 33-37
07428413
10.1016/S0742-8413(96)00139-9
Autor
Orellana, Myriam
Avalos, Nicolas
Abarca, Montserrat
Valdés, Elena
Institución
Resumen
Microsomal cytochrome P450 and peroxisomal activity were studied in liver of rats 7 days after two-thirds hepatectomy or bile duct ligation (BDL). Both surgical models decreased the hepatic microsomal cytochrome P450 content, but only cholestasis, produced by BDL, decreased the microsomal metabolism of lauric acid and aminopyrine, peroxisomal fatty acid β-oxidation and catalase activity. The microsomal and peroxisomal activities responded in a coordinate way to cholestasis and two-thirds hepatectomy. These results suggest a cause effect relationship between the microsomal cytochrome P450 and peroxisomal activity.