Artículo de revista
Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
Fecha
2018Registro en:
Scientific Reports Volumen: 8 Número de artículo: 963
10.1038/s41598-018-19324-y
Autor
Quinto Sánchez, Mirsha
Rothhammer Engel, Francisco
Institución
Resumen
Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies