Artículos de revistas
Genome wide association study for resistance to Caligus rogercresseyi in Atlantic salmon (Salmo salar L.) using a 50K SNP genotyping array
Fecha
2017Registro en:
Aquaculture 472 (2017): 61–65
10.1016/j.aquaculture.2016.04.008
Autor
Correa, Katharina
Lhorente, Jean Paul
Bassini, Liane
López, María E.
Di Genova, Alex
Maass Sepúlveda, Alejandro
Davidson, William S.
Yáñez López, José
Institución
Resumen
The sea louse (Caligus rogercresseyi) is an external parasite and considered one of the most important health
problems in the salmon farming industry. Resistance to conventional chemical treatments has been demonstrated.
Sufficient additive genetic variation has been determined to include selection for resistance to this parasite in
Atlantic salmon breeding programs. The aim of this study was to perform a GenomeWide Association Study in
order to dissect the genetic factors involved in the resistance to C. rogercresseyi, one of themost important species
of sea lice in the Chilean salmon farming. 2628 Atlantic salmon smolts, which had been experimentally infested
with C. rogercresseyi, were genotyped using a 50K SNP array. Genome Wide Association Analysis was conducted
using a polygenic model. A heritability of 0.12 for resistance to this louse species was estimated using genomic
information. This result was consistent with estimates from previous studies which used pedigree records in
the same population. Only one SNP, located on chromosome 21, was significant at a local level, explaining 0.5%
of the phenotypic variance and 4% of the genomic heritability for sea lice resistance. This SNP is located in an
intronic region of a predicted gene which codes for Collagen alpha-1. Our results suggest that resistance to
C. rogercresseyi can be considered a polygenic trait, controlled by many variants of relatively small effect. Thus
the incorporation of genomic information through genomic selection could be the most appropriate approach
for breeding purposes.
Statement of relevance: Caligus resistance has a polygenic genetic architecture.