Artículo de revista
Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor
Fecha
2016Registro en:
Cytoskeleton, October 2016 73:612–628
10.1002/cm.21312
Autor
González, Andrés
Moya Alvarado, Guillermo
González Billault, Christian
Bronfman, Francisca
Institución
Resumen
Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.